Ehrlichiosis presenting as severe sepsis and meningoencephalitis in an immunocompetent adult
Buzzard, Stephanie L. and Bissell, Brittany D. and Thompson Bastin, Melissa L.,, 5, e005162 (2018),
doi = https://doi.org/10.1099/jmmcr.0.005162,
publicationName = Microbiology Society,
issn = ,
abstract= Introduction. Ehrlichia are obligate intracellular pathogens transmitted to vertebrates by ticks. Case presentation. We report the case of a 59-year-old man who presented to the University of Kentucky Albert B. Chandler Medical Center (Lexington, KY, USA) after being found fallen down in the woods. A lumbar puncture revealed what appeared to be bacterial meningitis, yet cerebrospinal fluid cultures, Gram stains and a meningitis/encephalitis panel were inconclusive. However, an Ehrlichia DNA PCR of the blood resulted as being positive for Ehrlichia chaffeensis antibodies. The patient received a 14 day course of doxycycline, and recovered from his multiple organ failure. The aetiology of the ehrlichial meningoencephalitis was likely transmission through a tick-bite, due to the patient’s outdoor exposure. Conclusion. While it is rare to see Ehrlichia as a cause of meningitis, this illness can progress to severe multisystem disease with septic shock, meningoencephalitis or acute respiratory distress syndrome (ARDS). Those with compromised immunity are at a higher risk of developing the more severe form of the disease and have higher case fatality rates.,
language=,
type=