Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients

C. Gustavo De Moraes; Michele Pettito; Juan B. Yepez; Anavaj Sakuntabhai; Etienne Simon-Loriere; Mussaret B. Zaidi; Matthieu Prot; Claude Ruffie; Susan S. Kim; Rando Allikmets; Joseph D. Terwilliger; Joseph H. Lee; Gladys E. Maestre

doi:10.1099/jmmcr.0.005145

Volume 5, Issue 5

Case Report

Open Access

Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients

C. Gustavo De Moraes¹, Michele Pettito², Juan B. Yepez², Anavaj Sakuntabhai^3,4, Etienne Simon-Loriere^3,4, Mussaret B. Zaidi^5,6, Matthieu Prot^3,4, Claude Ruffie^7,8, Susan S. Kim⁹, Rando Allikmets¹, Joseph D. Terwilliger^10,11,12,13, Joseph H. Lee^11,14 and Gladys E. Maestre^15,16,17
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Affiliations: ¹ Department of Ophthalmology, Columbia University Medical Center, New York, NY, USA ² Clinica de Ojos de Maracaibo, Venezuela ³ Pasteur Institute, Functional Genetics of Infectious Diseases Unit, Paris, France ⁴ CNRS, URA 3012, Paris, France ⁵ Infectious Diseases Research Laboratory, Hospital General O'Horan, Merida, Mexico ⁶ Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA ⁷ Pasteur Institute, Viral Genomics and Vaccination Unit, Paris, France ⁸ CNRS, URA3015, Paris, France ⁹ In-patient Diabetes Unit, St. Peter’s Hospital, Albany, NY, USA ¹⁰ Departments of Psychiatry and Genetics and Development, Columbia University Medical Center, New York, NY, USA ¹¹ Sergievsky Center, Columbia University Medical Center, New York, NY, USA ¹² Division of Medical Genetics, New York State Psychiatric Institute, New York, NY, USA ¹³ Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland ¹⁴ Taub Institute and Department of Epidemiology, Columbia University Medical Center, New York, NY, USA ¹⁵ Laboratory of Neuroscience, University of Zulia, Maracaibo, Venezuela ¹⁶ Department of Biomedical Sciences, Division of Neurosciences, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA ¹⁷ Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA
*Correspondence: Gladys E. Maestre, [email protected]
Published: 01 May 2018 https://doi.org/10.1099/jmmcr.0.005145

Abstract

Introduction. Although the current Zika virus (ZIKV) epidemic is a major public health concern, most reports have focused on congenital ZIKV syndrome, its most devastating manifestation. Severe ocular complications associated with ZIKV infections and possible pathogenetic factors are rarely described. Here, we describe three Venezuelan patients who developed severe ocular manifestations following ZIKV infections. We also analyse their serological response to ZIKV and dengue virus (DENV).

Case presentation. One adult with bilateral optic neuritis, a child of 4 years of age with retrobulbar uveitis and a newborn with bilateral congenital glaucoma had a recent history of an acute exanthematous infection consistent with ZIKV infection. The results of ELISA tests indicated that all patients were seropositive for ZIKV and four DENV serotypes.

Conclusion. Patients with ZIKV infection can develop severe ocular complications. Anti-DENV antibodies from previous infections could play a role in the pathogenesis of these complications. Well-designed epidemiological studies are urgently needed to measure the risk of ZIKV ocular complications and confirm whether they are associated with the presence of anti-flaviviral antibodies.

Received: 25/01/2018
Accepted: 06/03/2018
Published Online: 01/05/2018

Keyword(s): arbovirus , congenital glaucoma , dengue , optic neuritis , steroid treatment , uveitis , vision loss and Zika virus

This is an open access article under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Erratum

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Corrigendum: Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients

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Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients

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Volume 5, Issue 5

Case Report

Open Access

Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients

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Erratum

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