1887

Abstract

is a relatively common environmental black yeast with worldwide distribution and is a rare cause of fungal infection, mostly in patients with certain predisposing factors. Due to the rarity of the infection, little is known about the specific predisposing factors, way of infection or treatment.

Here, we report what is to our knowledge the first case of infection in a child after allogeneic stem cell transplantation. We also review all paediatric cases reported in the literature since 1993.

This is, to our knowledge, the first reported case of infection in a child after allogeneic stem cell transplantation. This report should increase the awareness of in immunocompromised paediatric patients, particularly after stem cell transplantation.

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2017-06-08
2024-04-20
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References

  1. Kantarcioglu AS, Hoog GS. Infections of the central nervous system by melanized fungi: a review of cases presented between 1999 and 2004. Mycoses 2004; 47:4–13 [View Article]
    [Google Scholar]
  2. Mukaino T, Koga T, Oshita Y, Narita Y, Obata S et al. Exophiala dermatitidis infection in non-cystic fibrosis bronchiectasis. Respir Med 2006; 100:2069–2071 [View Article][PubMed]
    [Google Scholar]
  3. Matsumoto T, Matsuda T, McGinnis MR, Ajello L. Clinical and mycological spectra of Wangiella dermatitidis infections. Mycoses 1993; 36:145–155 [View Article][PubMed]
    [Google Scholar]
  4. Kondori N, Lindblad A, Welinder-Olsson C, Wennerås C, Gilljam M. Development of IgG antibodies to Exophiala dermatitidis is associated with inflammatory responses in patients with cystic fibrosis. J Cyst Fibros 2014; 13:391–399 [View Article][PubMed]
    [Google Scholar]
  5. Blasi B, Tafer H, Tesei D, Sterflinger K. From glacier to sauna: RNA-seq of the human pathogen black fungus Exophiala dermatitidis under varying temperature conditions exhibits common and novel fungal response. PLoS One 2015; 10:e0127103 [View Article][PubMed]
    [Google Scholar]
  6. Sudhadham M, Prakitsin S, Sivichai S, Chaiyarat R, Dorrestein GM et al. The neurotropic black yeast Exophiala dermatitidis has a possible origin in the tropical rain forest. Stud Mycol 2008; 61:145–155 [View Article][PubMed]
    [Google Scholar]
  7. Zalar P, Novak M, de Hoog GS, Gunde-Cimerman N. Dishwashers – a man-made ecological niche accommodating human opportunistic fungal pathogens. Fungal Biol 2011; 115:997–1007 [View Article][PubMed]
    [Google Scholar]
  8. Lian X, de Hoog GS. Indoor wet cells harbour melanized agents of cutaneous infection. Med Mycol 2010; 48:622–628 [View Article][PubMed]
    [Google Scholar]
  9. Zupančič J, Novak Babič M, Zalar P, Gunde-Cimerman N. The black yeast Exophiala dermatitidis and other selected opportunistic human fungal pathogens spread from dishwashers to kitchens. PLoS One 2016; 11:e0148166 [View Article][PubMed]
    [Google Scholar]
  10. Zeng JS, Sutton DA, Fothergill AW, Rinaldi MG, Harrak MJ et al. Spectrum of clinically relevant Exophiala species in the United States. J Clin Microbiol 2007; 45:3713–3720 [View Article][PubMed]
    [Google Scholar]
  11. Patel AK, Patel KK, Darji P, Singh R, Shivaprakash MR et al. Exophiala dermatitidis endocarditis on native aortic valve in a postrenal transplant patient and review of literature on E. dermatitidis infections. Mycoses 2013; 56:365–372 [View Article][PubMed]
    [Google Scholar]
  12. Suzuki K, Nakamura A, Fujieda A, Nakase K, Katayama N. Pulmonary infection caused by Exophiala dermatitidis in a patient with multiple myeloma: a case report and a review of the literature. Med Mycol Case Rep 2012; 1:95–98 [View Article][PubMed]
    [Google Scholar]
  13. Chalkias S, Alonso CD, Levine JD, Wong MT. Emerging pathogen in immunocompromised hosts: Exophiala dermatitidis mycosis in graft-versus-host disease. Transpl Infect Dis 2014; 16:616–620 [View Article][PubMed]
    [Google Scholar]
  14. Chang X, Li R, Yu J, Bao X, Qin J. Phaeohyphomycosis of the central nervous system caused by Exophiala dermatitidis in a 3-year-old immunocompetent host. J Child Neurol 2009; 24:342–345 [View Article]
    [Google Scholar]
  15. Matos T, Haase G, Gerrits van den Ende AHG, de Hoog GS. Molecular diversity of oligotrophic and neurotropic members of the black yeast genus Exophiala, with accent on E. dermatitidis . Antonie van Leeuwenhoek 2003; 83:293–303 [View Article][PubMed]
    [Google Scholar]
  16. Krzyściak PM, Pindycka-Piaszczyńska M, Piaszczyński M. Chromoblastomycosis. Postepy Dermatol Alergol 2014; 31:310–321 [View Article]
    [Google Scholar]
  17. Duarte AP, Pagnocca FC, Baron NC, Melhem MS, Palmeira GA et al. In vitro susceptibility of environmental isolates of Exophiala dermatitidis to five antifungal drugs. Mycopathologia 2013; 175:455–461 [View Article][PubMed]
    [Google Scholar]
  18. Li DM, Li RY, de Hoog GS, Sudhadham M, Wang DL. Fatal Exophiala infections in China, with a report of seven cases. Mycoses 2011; 54:e136e142 [View Article][PubMed]
    [Google Scholar]
  19. Blaschke-Hellmessen R, Lauterbach I, Paul KD, Tintelnot K, Weissbach G. [Detection of Exophiala dermatitidis (Kano) De Hoog 1977 in septicemia of a child with acute lymphatic leukemia and in patients with cystic fibrosis]. Mycoses 1994; 37:89–96 (in German)[PubMed]
    [Google Scholar]
  20. Nachman S, Alpan O, Malowitz R, Spitzer ED. Catheter-associated fungemia due to Wangiella (Exophiala) dermatitidis . J Clin Microbiol 1996; 34:1011–1013[PubMed]
    [Google Scholar]
  21. Alabaz D, Kibar F, Arikan S, Sancak B, Celik U et al. Systemic phaeohyphomycosis due to Exophiala (Wangiella) in an immunocompetent child. Med Mycol 2009; 47:653–657 [View Article][PubMed]
    [Google Scholar]
  22. Hong KH, Kim JW, Jang SJ, Yu E, Kim EC. Liver cirrhosis caused by Exophiala dermatitidis . J Med Microbiol 2009; 58:674–677 [View Article][PubMed]
    [Google Scholar]
  23. Russo JP, Raffaeli R, Ingratta SM, Rafti P, Mestroni S. Cutaneous and subcutaneous phaeohyphomycosis. Skinmed 2010; 8:366–369[PubMed]
    [Google Scholar]
  24. Hu B, Li S, Hu H, Chen T, Guo X et al. [Central nervous system infection caused by Exophiala dermatitidis in a case and literature review]. Zhonghua er ke za zhi 2014; 52:620–624 (in Chinese)
    [Google Scholar]
  25. Griffard EA, Guajardo JR, Cooperstock MS, Scoville CL. Isolation of Exophiala dermatitidis from pigmented sputum in a cystic fibrosis patient. Pediatr Pulmonol 2010; 45:508–510 [View Article][PubMed]
    [Google Scholar]
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