%0 Journal Article %A Hori, Masatoshi %A Nakayama, Akifumi %A Kitagawa, Daisuke %A Fukushima, Hidetada %A Asai, Hideki %A Kawai, Yasuyuki %A Okuchi, Kazuo %T A case of Vibrio vulnificus infection complicated with fulminant purpura: gene and biotype analysis of the pathogen %D 2017 %J JMM Case Reports, %V 4 %N 5 %@ 2053-3721 %C e005096 %R https://doi.org/10.1099/jmmcr.0.005096 %K fulminant purpura %K biotype 3 %K genotype E %K primary septicemia %K Vibrio vulnificus %I Microbiology Society, %X Introduction. Vibrio vulnificus (V. vulnificus) causes a severe infection that develops in the compromised host. Its pathophysiology is classified into three types: (1) primary septicaemia, (2) gastrointestinal illness pattern and (3) wound infection pattern. Of these, primary septicaemia is critical. V. vulnificus can be classified into three biotypes and two genotypes and its pathogenicity is type-dependent. Case presentation. A 47-year-old man presented to a local hospital with chief complaints of fever, bilateral lower limb pain and diarrhoea. He had no history of foreign travel or known medical problems. He was in septic shock and developed fulminant purpura within 24 h of the onset. High-dose vasopressor and antibiotic administration failed to alter his status and he died 3 days after the onset of symptoms. V. vulnificus was isolated from blood, skin and nasal discharge cultures. Biotype and gene analysis of the microbe isolated identified it as Biotype 3, mainly reported in Israel in wound infections, and Genotype E, implicating an environmental isolate. These typing analyses indicated that the microbe isolated could be classified as a type with low pathogenicity. Conclusion. This case highlighted that Biotype 3 and Genotype E can also cause primary septicaemia. Although the majority of reports on Biotype 3 have been from the Middle East, this experience with the present case provided evidence that the habitat of Biotype 3 V. vulnificus has been extending to East Asia as well. %U https://www.microbiologyresearch.org/content/journal/jmmcr/10.1099/jmmcr.0.005096