First report of fatal disseminated microsporidiosis in two inland bearded dragons Pogona vitticeps in Japan Shibasaki, Kojiro and Tokiwa, Toshihiro and Sukegawa, Akihiro and Kondo, Hirotaka and Tamukai, Kenichi and Haga, Yumiko and Ike, Kazunori,, 4, e005089 (2017), doi = https://doi.org/10.1099/jmmcr.0.005089, publicationName = Microbiology Society, issn = , abstract= Introduction. Encephalitozoon pogonae is a newly described pathogen belonging to the phylum Microsporidia. In Austria and the USA, this species has been isolated from fatal and disseminated cases of captive-bred inland bearded dragons. Here, we report the case of fatal disseminated microsporidiosis caused by E. pogonae in two bearded dragons in Japan. Case Presentation. The two lizards from different private households in Tokyo, Japan, had been brought to an animal hospital for examination. In both cases, the animal presented with a history of weight loss for several weeks. There were no improvements in clinical symptoms and the lizards deteriorated and finally died. Histopathological examination demonstrated necrotizing granulomatous inflammation attributed to disseminated microsporidian infection. Nucleotide sequencing of the nuclear ribosomal internal transcribed spacer region identified the microsporidian as E. pogonae with sequence identity of 100 %. Conclusion. We report the first case, to our knowledge, of disseminated microsporidiosis caused by E. pogonae in inland bearded dragons in Japan. Although it is difficult to diagnose prenatally since the signs are nonspecific, the disease should be considered in the differential diagnosis of chronic infections that do not respond to antibiotics., language=, type=