1887

Abstract

Introduction:

species usually cause opportunistic infections, and the frequency of these infections is increasing owing to the growing population of immunocompromised hosts. However, species may sometimes cause an infection disease in immunocompetent hosts. infections are the least common and are very rare.

Case presentation:

Herein, we report the first case of a pulmonary infection with in a 61-year-old Japanese woman with a history of hyperlipidaemia and bronchiectasis and a 6-month history of non-productive hacking cough. A sample of bronchial lavage fluid obtained by bronchofiberscopy showed filamentous branching gram-positive rods and acid-fast filamentous branching rods, and a colony of suspected was cultured. Based on 16S rRNA, , and gene sequence analyses and biochemical and physiological properties, the strain was identified as The strain was resistant to the antimicrobial agents amoxicillin-clavulanic acid, clarithromycin, minocycline, gentamycin, tobramycin, ciprofloxacin and trimethoprim-sulfamethoxazole. The patient was treated with biapenem followed by intravenous amikacin and oral linezolid.

Conclusion:

Despite its rarity, the species require attention owing to the existence of multidrug-resistant strains.

Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.005054
2016-07-11
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/3/4/jmmcr005054.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.005054&mimeType=html&fmt=ahah

References

  1. Beaman B. L., Beaman L. 1994; Nocardia species: host-parasite relationships. Clin Microbiol Rev 7:213–264 [View Article][PubMed]
    [Google Scholar]
  2. Brown-Elliott B. A., Brown J. M., Conville P. S., Wallace, R. J. 2006; Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy. Clin Microbiol Rev 19:259–282 [View Article][PubMed]
    [Google Scholar]
  3. Burgert S. J. 1999; Nocardiosis: a clinical review. Infect Dis Clin Pract 8:27–32 [CrossRef]
    [Google Scholar]
  4. Carrasco G., Valdezate S., Garrido N., Villalón P., Medina-Pascual M. J., Sáez-Nieto J. A. 2013; Identification, typing, and phylogenetic relationships of the main clinical Nocardia species in spain according to their gyrB and rpoB genes. J Clin Microbiol 51:3602–3608 [View Article][PubMed]
    [Google Scholar]
  5. Clinical and Laboratory Standards Institute (CLSI) 2011 Susceptibility Testing of Mycobacteria, Nocardia, and Other Aerobic Actinomycetes, 2nd ed, vol 31, no. 5. Approved standard M24-A2 Wayne, PA: National Committee for Clinical Laboratory Standards;
  6. Clinical and Laboratory Standards Institute 2008 Interpretive Criteria for Identification of Bacteria and Fungi by DNA Target Sequencing. Approved standard MM18-A, 1st ed Wayne, PA: Clinical and Laboratory Standards Institute;
  7. Flateau C., Jurado V., Lemaître N., Loïez C., Wallet F., Saiz-Jimenez C., Decoene C., Bergeron E., Boiron P. et al. 2013; First case of cerebral abscess due to a novel Nocardia species in an immunocompromised patient. J Clin Microbiol 51:696–700 [View Article][PubMed]
    [Google Scholar]
  8. Kim S. Y., Lee K. L., Lee D. M., Jeong J. H., Moon S. M., Seo Y. H., Yoo C. J., Yang D., Cho Y. K., Park Y. S. 2015; Nocardia brain abscess in an immunocompetent patient. Infect Chemother 47:304 [View Article][PubMed]
    [Google Scholar]
  9. Lederman E. R., Crum N. F. 2004; A case series and focused review of nocardiosis: clinical and microbiologic aspects. Medicine 83:300–313[PubMed] [CrossRef]
    [Google Scholar]
  10. Lerner P. I. 1996; Nocardiosis. Clin Infect Dis 22:891–905 [View Article][PubMed]
    [Google Scholar]
  11. McTaggart L. R., Richardson S. E., Witkowska M., Zhang S. X. 2010; Phylogeny and identification of Nocardia species on the basis of multilocus sequence analysis. J Clin Microbiol 48:4525–4533 [View Article][PubMed]
    [Google Scholar]
  12. Minero M. V., Marín M., Cercenado E., Rabadán P. M., Bouza E., Muñoz P. 2009; Nocardiosis at the turn of the century. Medicine 88:250–261 [View Article][PubMed]
    [Google Scholar]
  13. Moylett E. H., Pacheco S. E., Brown-Elliott B. A., Perry T. R., Buescher E. S., Birmingham M. C., Schentag J. J., Gimbel J. F., Apodaca A. et al. 2003; Clinical experience with linezolid for the treatment of nocardia infection. Clin Infect Dis 36:313–318 [View Article][PubMed]
    [Google Scholar]
  14. Owen H., Buckle K., Olm J., Leitner M., Pandey S., Gaughan J. B., Sullivan M. L., Lees A. M., Gibson J. S. 2015; Isolation of Nocardia mexicana from focal proliferative tenosynovitis and arthritis in a steer. Aust Vet J 93:170–173 [View Article][PubMed]
    [Google Scholar]
  15. Rivero A., García-Lázaro M., Pérez-Camacho I., Natera C., del Carmen Almodovar M., Camacho A., Torre-Cisneros J. 2008; Successful long-term treatment with linezolid for disseminated infection with multiresistant Nocardia farcinica . Infection 36:389–391 [View Article][PubMed]
    [Google Scholar]
  16. Rodríguez-Nava V., Couble A., Molinard C., Sandoval H., Boiron P., Laurent F. 2004; Nocardia mexicana sp. nov., a new pathogen isolated from human mycetomas. J Clin Microbiol 42:4530–4535 [CrossRef]
    [Google Scholar]
  17. Saubolle M. A., Sussland D. 2003; Nocardiosis: review of clinical and laboratory experience. J Clin Microbiol 41:4497–4501 [View Article][PubMed]
    [Google Scholar]
  18. Shen T., Wu L., Geng L., Wei Z., Zheng S. 2011; Successful treatment of pulmonary Nocardia farcinica infection with linezolid: case report and literature review. Braz J Infect Dis 15:486–489 [View Article][PubMed]
    [Google Scholar]
  19. Stackebrandt E., Ebers J. 2006; Taxonomic parameters revisited: tarnished gold standards. Microbiol Today 33:152–155
    [Google Scholar]
  20. Takeda K., Kang Y., Yazawa K., Gonoi T., Mikami Y. 2010; Phylogenetic studies of Nocardia species based on gyrB gene analyses. J Med Microbiol 59:165–171 [View Article][PubMed]
    [Google Scholar]
  21. Tanioka K., Nagao M., Yamamoto M., Matsumura Y., Tabu H., Matsushima A., Uemura K., Matsumoto R., Ito Y. et al. 2012; Disseminated Nocardia farcinica infection in a patient with myasthenia gravis successfully treated by linezolid: a case report and literature review. J Infect Chemother 18:390–394 [View Article][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmmcr/10.1099/jmmcr.0.005054
Loading
/content/journal/jmmcr/10.1099/jmmcr.0.005054
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error