1887

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Volume 68, Issue 11

Evaluation of antibody persistence after a four-dose primary hepatitis B vaccination and anamnestic immune response in children under 6 years Free

Abstract

Tunisia is an intermediate hepatitis B virus (HBV) endemic country. The vaccination against hepatitis B was introduced in 1995 including four doses with a first dose administrated at birth. Decreasing the level of antibodies against hepatitis B surface antigen (anti-HBs) over time can be alarming. This study was conducted to explore the anti-HBV immune response among children under 6 years old, vaccinated according to the national vaccination schedule, by evaluating the immunological response to primary vaccination and by exploring the anamnestic immune response to a booster dose.

We conducted a cross-sectional prospective study from June 2016 to June 2017 (=180), based on voluntary participation. Children were recruited from the public pediatric ward sectors in Sahloul University Hospital of Sousse in Central Tunisia. An anti-HB titre was determined based on electro-chemiluminescence micro-particle immunoassay (ECLIA), using Elecsys Anti-HBs II kit, Roche.

Mean age at the time of enrollment in the study was 33±14.8 months. The seroprotection rate was 77.2 %. The anti-HB titre differed significantly between the different age groups (=0.002). The predicting variable for having no seroprotective antibody level was older age. Children with anti-HB levels <10 IU l were offered an additional dose of HBV vaccine. Anamnestic response 1 month after the challenge dose was observed in 100 % of subjects. The probability of developing a high antibody response, following the booster dose increased in conjunction with an increased pre-booster antibody level.

The response to a booster dose suggests the persistence of immune memory in almost all vaccinated individuals. Although a booster dose increases substantially anti-HB titre, the clinical relevance of such an increase remains unknown.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): anamnestic response , Hepatitis B , seroprotection and vaccination
© 2019 The Authors
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2019-11-01
2024-05-19
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Evaluation of antibody persistence after a four-dose primary hepatitis B vaccination and anamnestic immune response in children under 6 years
J. Med. Microbiol. 68, 1686 (2019); https://doi.org/10.1099/jmm.0.001086
/content/journal/jmm/10.1099/jmm.0.001086
/content/journal/jmm/10.1099/jmm.0.001086
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